Electromechanical Modeling of the Heart in Healthy and Pulmonary Arterial Hypertension Cases

Authors

1 MSc, Department of Mechatronics Engineering, Faculty of Mechanical Engineering, University of Tabriz, Tabriz, Iran

2 Assist. Prof., Department of Mechatronics Engineering, Faculty of Mechanical Engineering, University of Tabriz, Tabriz, Iran

Abstract

Cardiovascular diseases are the leading cause of death worldwide. Computer simulations of cardiac function are gradually becoming a powerful tool to better understand cardiac behavior and support clinical decision-making. However, right heart modeling is still in its early stages. Pulmonary hypertension is a pathophysiological disorder that may involve several clinical conditions. This study presents a fully coupled multiscale mathematical and numerical model of cardiac electromechanics with idealized biventricular geometry for normal subjects and pulmonary hypertension patients in COMSOL software. Muscle fibers that control electrical conduction and myocardial contraction, is one of the vital factors for the electromechanical simulation of the heart which was defined using a rule-based method. Windkessel blood circulation model was used to calculate systemic and pulmonary pressures. Blood circulation was modeled with a straightforward approach for the left and right ventricles. Lastly, alterations in the functional behavior of the heart were evaluated between individuals without pulmonary hypertension and healthy subjects. It was observed that right ventricular pressure increases in pulmonary arterial hypertension and ejection fraction decreases.

Keywords

Main Subjects

References

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Journal of Solid and Fluid Mechanics
Volume 14, Issue 5
November and December 2024
Pages 27-37

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