On the Effect of Blood Flow and Oxygen Mass Transfer on Development of Atherosclerosis

Authors

1 Student Mech. Eng., Ferdowsi Univ., Mashhad, Iran

2 Prof., Mech. Eng., Ferdowsi Univ.

3 Mech. Eng., Energ. Dept., Inst. Sci. High Tech. Envir. Sci., Graduate Univ. Adv. Tech

Abstract

In curved arteries, since geometry and hemodynamics are diffrent from straight ones, balanced oxygen distribution on the wall of artery will be disrupted. This disorder has a significant contribution in genesis and development of Atherosclerosis plaques. In this study, the blood oxygen mass transport in a 3D curved artery and its wall were investigated. In order to find the distribution of oxygen concenteration along the vessel, oxygen mass transport equations and their boundary conditions were solved, numerically. The oxygen carried by Hemoglobin and oxygen consumed in the avascular region were considered as two important physiological parameters. Results indicated that, the presence of centrifugal forces and formation of secondary flows in curved geometries, cause a considerable decrease in oxygen mass transport to the inner bend wall in comparison to outer one. Furthermore, with increase in Reynolds number and decrease in curvature radius, secondary flows become more powerful which cause an enhancement in the flow mixing and as a result reduce the oxygen concentration difference between the outer and the inner bend walls. These results help to predict the potential region for formation of Atherosclerosis plaques.

Keywords

Main Subjects

References

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Journal of Solid and Fluid Mechanics
Volume 4, Issue 2 - Serial Number 2
May and June 2014
Pages 119-132

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